Monday, March 23, 2015

Can Medicine Lower Your Insulin Level?

As promised, I stated in my last post that I would shed some light on a medicine that lowers your insulin level.  As you might recall, high insulin levels lead to storage of body fat resulting in an increased body fat mass.  Excess body fat leads to disease - regardless of your weight or your BMI.  You can be of "normal weight and BMI" but have a high body fat percentage and this puts you at risk for type two diabetes, abnormal lipid panels, high blood pressure, vascular disease, etc.

This is the reason that I put so much emphasis on restraint when it comes to carbohydrate intake.  At the same time, I constantly emphasize getting the correct amount of protein in your diet, and I emphasize the fact that the consumption of most dietary fats is not the enemy.  The idea is this: carbohydrates can cause large increases in insulin, and protein and fat do not.  So, that covers the diet side of things.  Is there a medicine that helps bring down insulin levels?  The answer is yes.

Metformin is a medicine that has been on the market for about 50 years.  It is a medicine that is used to keep pre-diabeties (know as insulin resistance) from advancing to diabetes.  It works by making cell membranes more sensitive to insulin so that insulin passes easily from the serum to the inside of the cell - this lowers serum insulin levels.  It is this effect that aids in weight loss from decreasing body fat.  Think of it this way - a lower insulin level lowers the "fat storing signal" to your body.  In the presence of a carbohydrate restricted diet, the "fat burning signal" acts unopposed.  

Metformin can be used in conjunction with phentermine.  The major contra-indication is renal insufficiency or renal failure.  Most of my patients do not have this.  The major side effect is GI upset if you take it on an empty stomach - so take it after the biggest meal of the day.  It is cheap and we stock it at my practice.  The cost for a months supply is between $10 and $15 depending on the dose.

My next post will discuss how to know if you have insulin resistance, and therefore need a drug like metformin.  Don't forget - know your lean mass and fat mass with precision; have your Inbody 770 test performed in March - its only $20.

Dr. Simonds

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